What Is Profhilo, and Who Is It For? Restoring Skin Structure From Within

As doctors who have spent years caring for patients and offering guidance on skin rejuvenation, we know that finding a way to bring back radiant, healthy skin with strong structure from within is something many people are searching for. Today, we’d like to introduce you to Profhilo, a treatment classified as a standout ‘Bioremodeling Agent,’ specifically designed to stimulate collagen and elastin production in the skin. It helps restore skin structure, leaving skin firmer, more elastic, and hydrated all over the face. Who is this treatment for, and what can it help with? Let’s find out in this article.

What Is Profhilo? Stimulating Collagen to Restore Skin Structure

Profhilo is a skin-structure and quality-improving treatment from Switzerland, certified safe by both the European CE Mark and Thailand’s FDA. What makes Profhilo stand out is its key ingredient, Hyaluronic Acid, at an exceptionally high purity and concentration of 64 mg, produced using a proprietary technology called ‘NAHYCO Hybrid Technology’ by IBSA Group, a global leader in HA production.

What makes Profhilo especially interesting is the form of Hyaluronic Acid it uses, known as ‘Non-crosslinked Hyaluronic Acid,’ which has a light texture and high purity, making it highly effective at stimulating collagen and elastin production for deep skin structure renewal.

How Does Profhilo Work?

Profhilo combines high-molecular-weight hyaluronic acid (H-HA) with low-molecular-weight hyaluronic acid (L-HA), which benefits the skin and helps results last longer.

When Profhilo is injected into the skin, the Non-crosslinked Hyaluronic Acid disperses and works deep within the skin, focusing on stimulating structural renewal, the key to restoring youthful-looking skin. This mechanism works in three main ways:

Deeply Stimulating New Skin Structure

Profhilo works to awaken skin cells and enhance their function, helping to reduce the appearance of wrinkles and sagging while helping repair scars for smoother-looking skin.

Renewing the Extracellular Matrix (ECM)

Profhilo helps improve the extracellular environment, known as the ECM, an essential structure that nourishes and supports healthy skin cell function. This helps skin cells work better, builds up the skin’s protective barrier, stimulates collagen and elastin fiber production, and helps healthy fat cells beneath the skin last longer, which benefits facial youthfulness.

Building New Skin Fibers and Collagen

Profhilo helps build various types of new collagen, which are essential to skin strength, making overall skin structure stronger, preventing fragility, and helping wounds heal faster than before.

How Is Profhilo Different From a Conventional HA Filler?

Many people mistakenly believe Profhilo is a type of filler, since its main ingredient is also hyaluronic acid. Medically, however, Profhilo is classified as a treatment focused on improving skin quality, not a filler focused on replacing lost volume. Here’s how Profhilo and HA filler compare:

A conventional filler uses Crosslinked Hyaluronic Acid, which contains a cross-linking agent that keeps the HA stable, allowing it to smooth wrinkles and fill in lost volume.
Profhilo uses Non-crosslinked Hyaluronic Acid, which contains no BDDE cross-linking agent. This gives it different properties: it doesn’t add volume the way a filler does, carries a low risk of allergic reaction or inflammation, and disperses well through the skin, working by stimulating skin cells to produce new collagen and elastin fibers, leaving skin firmer, tighter, and more elastic throughout the treated area.

In short, Profhilo is a treatment focused on improving skin quality and structure from within, restoring a youthful, healthy appearance.

What Can Profhilo Help With? What Are Its Key Strengths?

Profhilo has several standout qualities that make its results look natural and set it apart from other treatments:

A treatment with high-concentration, high-purity HA, giving it strong potential for skin rejuvenation
A treatment that delivers 2-in-1 results, adding hydration to the skin while stimulating collagen for firmness at the same time
A safe treatment that delivers natural-looking results, without causing allergic reactions or inflammation
A highly versatile treatment that can address concerns in nearly every area showing signs of aging, whether on the face, neck, or body

Who Is Profhilo Good For, and Who Should Avoid It?

Profhilo Is a Good Fit For

Those who want youthful, natural-looking skin without wanting to change their facial structure
Those with mild to moderate skin laxity
Those who want to restore elasticity, strength, and healthy-looking skin
Those who want smoother-looking skin with fewer wrinkles
Those who want to add hydration and stimulate collagen for plumper, smoother-looking skin

Profhilo Is Not Recommended For

Those with significant skin laxity
Those who want to add volume to the face
Those who want to see very fast results
Those with underlying health conditions or severe allergies

Where Can Profhilo Be Injected?

Another thing that makes Profhilo stand out in the aesthetics world is its ability to improve skin quality comprehensively, not just on the face, but in other areas that often show clear signs of aging. Profhilo is commonly injected in the following areas:

The face, to rejuvenate skin all over for a smoother, firmer, healthier look
The neck, to help sagging, wrinkled neck skin become firmer and more elastic
The hands, to add density and hydration to the skin on the backs of the hands, for a more youthful, healthier look
Scars or acne scars, to make them appear shallower and smoother through collagen stimulation and new skin structure
Areas of the body prone to sagging, such as the upper arms or abdomen, to add firmness and elasticity to that area

How Many Sessions of Profhilo Are Needed to See Results, and How Long Do Results Last?

Doctors generally recommend two sessions of Profhilo, spaced one month apart, to continuously stimulate skin structure. For those with more significant skin concerns, such as acne scarring, a third session may be considered to achieve more visible hydration and radiance within the first 7–14 days, with clear results within 1–2 months.

Profhilo results last approximately 6–12 months, and treatment can be repeated to help maintain a youthful appearance every 6 months.

What Results Can I Expect After Profhilo?

Profhilo plays an important role in stimulating collagen and elastin in the skin, helping to reduce wrinkles and sagging while restoring balance to skin structure so it functions fully again. This leaves skin looking overall more youthful, healthy, and natural.

During the first 1–2 weeks after injection, you’ll begin to notice the first difference: skin looking noticeably more hydrated and radiant. Then, after about 1–2 months, once the hyaluronic acid has fully stimulated collagen and elastin production, you’ll see the full results: skin that’s noticeably firmer, smoother, and more elastic, with a visible reduction in fine lines.

Why Get Profhilo at ATier Wellness

At ATier Wellness, we’re committed to offering Profhilo under our philosophy, “ATier, A Timeless You.” With a deep understanding of how this innovation works, our team of expert doctors carefully analyzes each patient’s skin condition to choose a precise injection technique, allowing the product to disperse effectively and restore strong skin structure from within.

Every step is guided by a doctor who trains other doctors, with years of experience. Led by Dr. Weerawit Wateetip (Dr. Link), a dermatology specialist who has been invited to help lead treatment protocols and share his expertise, injection techniques, and the latest beauty trends with doctors nationwide, giving you confidence that you’ll receive treatment using correct, standard-compliant techniques.
Only genuine, reliable Profhilo products. ATier Wellness selects only tools and products that meet high standards of quality, verifiable at every step, which is something our clinic prioritizes for everyone’s safety and best results.
Quality confirmed by ATier-level standards. Our commitment to delivering an outstanding experience has earned our clinic prestigious national awards year after year, affirming our commitment to quality and to using the latest technology alongside standard-compliant care.
Comprehensive beauty care. ATier Wellness is a beauty center that covers every dimension of beauty, from dermatology and surgery to anti-aging medicine, allowing us to plan and deliver comprehensive skin rejuvenation care.

Profhilo Pricing at ATier Wellness

The price of Profhilo treatment varies by clinic. One vial of Profhilo contains 2 cc. At ATier Wellness, our Profhilo pricing is as follows:

Profhilo treatment: 25,000 THB per 2 cc

How Is Profhilo Different From Sculptra, Radiesse, Gouri, and Juvelook?

There are several treatments today that focus on stimulating collagen and rejuvenating the skin, each designed with a different purpose in mind. Here’s how the key strengths of these popular skin-rejuvenation treatments compare:

Profhilo: Stands out for restoring skin structure and adding hydration across the skin, from the superficial to mid layers, for firmer, more radiant, natural-looking skin.
Sculptra: Stands out for adding volume to the deeper layers of skin, well suited to those who want to restore overall facial structure and address moderate to significant sagging.
Radiesse: Stands out for strengthening facial structure and stimulating collagen production in the skin.
Gouri and Juvelook: Use a substance classified as Liquid PDO, a type of polymer known for targeted collagen stimulation, which can be applied in various ways depending on the doctor’s injection technique.

Is Profhilo Dangerous? What Side Effects Can Occur After Injection?

Profhilo treatment is not dangerous, since its main ingredient is high-purity hyaluronic acid free of chemical cross-linking agents (Non-BDDE), which greatly reduces the chance of allergic reaction or inflammation. It’s also certified by both the European FDA and Thailand’s FDA.

Common side effects of Profhilo treatment may include needle marks, minor swelling from the product, or bruising, which typically resolve on their own within 5–7 days and are not considered dangerous when the treatment is performed by an experienced doctor at a standard-compliant clinic.

What to Know Before Getting Profhilo

Before deciding on any treatment, patients should first understand what specific skin concern that treatment is designed to address, to ensure the results meet their expectations. Profhilo treatment is designed primarily to restore skin structure, not to add volume the way a filler does, making it well suited for patients who want to address the following concerns

1. Skin Quality and Elasticity Concerns

Profhilo is well suited for those who feel their skin looks “loose,” lacking elasticity and firmness, as well as feeling dehydrated and rough, but who aren’t ready for a surgical procedure or volumizing treatment.

2. Wrinkles and Skin Texture Concerns

Profhilo is well suited for those with fine lines, acne scars, and scarring that leaves skin looking uneven. This treatment helps stimulate collagen and elastin to smooth the skin, making scars appear shallower and skin tone more even.

In short, if your goal is youthful, healthy-looking skin, a face that looks fresh, plump, and naturally radiant, with a focus on improving skin quality and structure from within, Profhilo treatment is certainly the right choice for you.

How to Prepare Before Getting Profhilo

Preparing your body and skin before injection is an important step that helps boost the effectiveness of collagen stimulation from Profhilo and reduces the chance of unwanted side effects. Be sure to follow these steps:

Avoid certain supplements and medications that affect blood clotting, such as vitamin E, fish oil, and aspirin, stopping at least 1 week before your treatment.
Avoid alcohol and smoking for at least 24 hours before treatment.
Avoid activities that may irritate or inflame the skin, such as exfoliating the treatment area.
Avoid strenuous activity or anything that significantly raises your heart rate, for 1–2 days before treatment.
Share your complete health history with your doctor, including any underlying conditions or medications you’re currently taking, so your doctor can properly assess and plan your treatment.

How to Care for Your Skin After Profhilo

After your Profhilo treatment, taking proper care of your skin during the first 2–3 days is very important. It helps your skin recover faster, reduces side effects, and allows the hyaluronic acid to work at full effectiveness in stimulating collagen. Here’s what to do:

Avoid touching or bumping the treated area for the first 24 hours, to prevent infection and allow the product to disperse properly.
Avoid strenuous exercise or activities that make your body hot and cause heavy sweating, for the first 24–48 hours.
Avoid exposure to heat of any kind, as it may irritate the skin or cause further swelling.
Avoid alcoholic beverages in the first few days, to reduce the risk of bruising and support proper skin recovery.
You can apply your regular moisturizer or skincare as usual, but choose gentle products free of irritating ingredients.
Drink enough water each day to keep your skin hydrated and support faster recovery.

FAQ: Frequently Asked Questions About Profhilo

Who Is Profhilo Good For?

Profhilo treatment is well suited for those who want to rejuvenate their skin overall and address sagging skin and loss of elasticity caused by aging, without wanting the more dramatic facial changes that come with a filler treatment.

How Many Days Until I See Results From Profhilo?

Profhilo treatment begins showing improvements in skin health within 1–2 weeks after injection, with clear results in lifting and plumper, healthier-looking skin within 1–2 months.

Is Profhilo Dangerous? What Are the Side Effects?

Profhilo treatment is not dangerous, since it uses high-purity, high-concentration hyaluronic acid. Side effects are usually temporary and resolve on their own quickly, such as redness, swelling, or minor bruising at the injection site.

How Many Sessions of Profhilo Are Needed?

Doctors generally recommend two sessions of Profhilo, spaced 30 days apart, and treatment can be repeated every 6–8 months, depending on your skin condition and individual needs.

How Long Does Profhilo Last?

Profhilo results last approximately 6–8 months, depending on your skin condition and aftercare.

Is Profhilo Good?

Profhilo is a skin-rejuvenating treatment whose main ingredient is high-purity, high-concentration hyaluronic acid, focused on restoring skin structure for firmer, more elastic, hydrated skin with natural-looking results. It’s well suited for those who want to address sagging skin and loss of elasticity caused by aging, delivering results gradually but sustainably, lasting 6–12 months. This makes Profhilo an excellent choice for anyone looking for a way to rejuvenate their skin’s health from within.